In meta-analyses of GWAS results in 20,890 CHARGE participants of European ancestry, we identified genome-wide significant associations with FEV1/FVC for SNPs in seven novel independent loci (GPR126, ADAM19, AGER-PPT2, FAM13A, PTCH1, PID1, and HTR4) and with FEV1 for one novel independent locus annotated by at least three genes (INTS12-GSTCD-NPNT). The SpiroMeta consortium independently reported genome-wide significant associations of GSTCD, HTR4, AGER, TNS1, and THSD4 with FEV1/FVC and FEV1 in an independent sample of 20,228 individuals of European ancestry (accompanying manuscript). Both consortia confirm previous GWAS findings implicating the HHIP region for FEV1/FVC10.
