sequence alignments data downloaded from Targetscan 6.2. The polymorphic miRNA target sites were assigned into four classes: ‘D' (the derived allele disrupts a conserved miRNA site), ‘N' (the derived allele disrupts a nonconserved miRNA site), ‘C' (the derived allele creates a new miRNA site) and ‘O' (other cases when the ancestral allele cannot be determined unambiguously). We calculated the differences in context + scores between the reference and derived alleles for each SNP or INDEL in the miRNA target sites. A more negative value of the context + score difference indicates an increased likelihood that the polymorphism significantly altered miRNA targeting of the sequence.
