tested. The PRS were calculated after using P-value-informed clumping with a LD cut-off of R2 = 0.3 within a 500 kb window and excluding the major histocompatibility complex region of the genome because of its complex LD structure. The individual PRS generated were standardized and entered into a logistic regression model that included the main effect (PRS) and the effect of the interaction term (i.e., the product of PRS and the covariate for interaction). A false discovery rate (FDR q < 0.05) was applied to correct the PRS results for the number of thresholds and phenotypes tested.
