To identify effects accounting for the comorbidity among the SDs tested in the Yale-Penn cohort, AD, CaD, CoD, ND, and OD were entered as terms in the same logistic regression model (Fig. 1, left panel). We observed a consistent effect of AD and ND across all suicide traits tested, ranging from AD OR = 2.11 (95% CI = 1.91–2.33) and ND OR = 1.42 (95% CI = 1.29–1.57) for SI; to AD OR = 1.66 (95% CI = 1.4–1.96) and ND OR = 1.29 (95% CI = 1.1–1.51) for SA. Increased odds were observed with respect to CoD for SI (OR = 1.69; 95% CI = 1.52–1.88), SP (OR = 1.26; 95% CI = 1.08–1.48), and SA (OR = 1.51; 95% CI = 1.27–1.79), but not for persistent SI. CaD showed opposite effect directions for these traits; positive association with SI (OR = 1.62; 95% CI = 1.47–1.80) and negative association with SA (OR = 0.84; 95% CI = 0.72–0.97). An additional regression analysis was conducted to investigate the association of the severity of polysubstance dependence (i.e., the number of
