With a special eye on the somatic primary cell source, several studies are published depicting differences with respect to their epigenetic features. The so-called “epigenetic memory” describes the inheritance of the initial epigenomes and transcriptomes of the primary somatic cell type to the iPSCs. This means that aberrations acquired during reprogramming, like impaired functioning of imprinted genes, genetic instabilities, aberrant patterns of DNA methylation, or changed numbers of gene copies [28–30], as well as markers (like unique DNA methylation signatures) of the origin somatic cell, are inherited to the iPSCs [31, 32].
