Stronger evidence for association of rs1229984 with alcohol-related phenotypes in individuals of European descent began to accumulate from larger studies. In Denmark, ADH1B*2 was associated with hospitalization for AD (OR = 0.26 in men, 0.37 in women) and with fewer drinks/week and less heavy drinking in both men and women (Tolstrup et al., 2008, Linneberg et al., 2010). Germans with an ADH1B*2 allele drank less per day than those without (Drogan et al., 2012), and ADH1B*2 was strongly associated with AD (p=1.8×10−9) (Treutlein et al., 2014). A US study showed the protective effect of ADH1B*2 on risk for AD was close to that seen in East Asians (OR = 0.34, p= 6.6×10−10) and reduced the maximum drinks in a 24 h period (p=3×10−13) (Bierut et al., 2012). A study in Great Britain showed a similar effect, OR = 0.26 vs. all controls, 0.19 vs. screened controls (p=2.7×10−8) (Way et al., 2015).
