Fourth, based on these empirical estimates of SNP heritability and CGR for height, BMI, years of education, and self-rated health, we used the MetaGAP calculator to predict the number of expected hits and the expected PGS R2 for the most prominent studies to date for these traits. We found that our predictions are in moderate agreement with empirical observations. Our theory seems slightly conservative for smaller GWAS samples. For large-scale GWAS efforts our predictions were in line with the outcomes of these efforts. More accurate estimates of the number of truly associated loci may further improve the accuracy of our theoretical predictions.
