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Chunk #55 — Discussion

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Meta-GWAS Accuracy and Power (MetaGAP) Calculator Shows that Hiding Heritability Is Partially Due to Imperfect Genetic Correlations across Studies.
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Third, we used a sample of unrelated individuals from the Rotterdam Study, the Swedish Twin Registry, and the Health and Retirement Study, to estimate SNP-based heritability as well as the CGR for traits such as height and BMI. Although our CGR estimates have considerable standard errors, the estimates make it likely that for many polygenic traits the CGR is positive, albeit smaller than one.