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Chunk #54 — Discussion

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Meta-GWAS Accuracy and Power (MetaGAP) Calculator Shows that Hiding Heritability Is Partially Due to Imperfect Genetic Correlations across Studies.
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Second, we used simulations to demonstrate that our theory is robust to several violations of the assumptions about the underlying data-generating process, regarding the relation between allele frequency and effect size, the distribution of allele frequencies, and the factors contributing to CGR. Further research needs to assess whether our theoretical predictions are also accurate under an even broader set of scenarios (e.g., when studying a binary trait).