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Chunk #40 — MEA technology — Applications of in vitro CMOS-based MEAs

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Revealing neuronal function through microelectrode array recordings.
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The two most prominent preparations investigated with in vitro CMOS MEAs so far are acute retina preparations from mice (Menzler and Zeck, 2011; Fiscella et al., 2012; Maccione et al., 2014), rats (Eickenscheidt et al., 2012; Lloyd et al., 2014; Stutzki et al., 2014), rabbits (Zeck et al., 2011; Ballini et al., 2014; Fiscella et al., 2014), guinea pig (Velychko et al., 2014) and humans (Reinhardt and Blickhan, 2014); and cultured neuronal cells from snails (Eversmann et al., 2003a), rats (Hafizovic et al., 2007; Heer et al., 2007; Gandolfo et al., 2010; Lambacher et al., 2010; Bakkum et al., 2013; Ballini et al., 2014) and chicken (Hafizovic et al., 2007). Additionally, data from acute slices of the cerebellum (Frey et al., 2009a; Obien et al., 2014), cortex (Ferrea et al., 2012; Medrihan et al., 2014) and olfactory bulb (Johnson et al., 2013a) have been shown. Also cultured cardiomyocytes were studied (DeBusschere and Kovacs, 2001; Heer et al., 2004; Imfeld et al., 2008; Sanchez-Bustamante et al., 2008; Huys et al., 2012) and first results from mice organotypic slices were presented (Gong et al., 2014).