Chunk #135 — IV. Results of tests of clustering within individual samples and tests of convergence between replicate samples for the same phenotypes — A. Polysubstance dependence vs controls (Samples 1 and 2)
Monte Carlo simulation trials that assess the probabilities that these results are due to chance find that none of 100,000 simulation trials identify as many SNPs that display nominally-positive differences between substance dependent vs control samples in both European and African American samples as observed here (thus p < 0.00001) [12]. 2,100 of 100,000 Monte Carlo simulation trials that each began by selecting 6,666 random SNPs provide chromosomal clustering as marked as that observed for the true reproducibly-positive SNPs (p = 0.021).
