Chunk #136 — IV. Results of tests of clustering within individual samples and tests of convergence between replicate samples for the same phenotypes — B. Methamphetamine dependent vs control (Samples 4 and 5)

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

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Nominally-positive SNPs from each of these two samples cluster together with ≤ 25 kb separation between nominally positive SNPs more than anticipated by chance. 846 clusters contain 3,749 of the 15,569 nominally-positive SNPs from Sample 4. 1,787 clusters contain 8,388 of the 25,538 nominally-positive SNPs from Sample 5. Such clustering is found in no Monte Carlo simulation trial (p < 0.0001 for both Sample 4 and Sample 5).