Chunk #137 — IV. Results of tests of clustering within individual samples and tests of convergence between replicate samples for the same phenotypes — B. Methamphetamine dependent vs control (Samples 4 and 5)
When we evaluated the genes that were identified by clustered, nominally-positive results from both Samples 4 and 5, we obtained evidence for replication and results that could not be expected by chance alone. This criterion for genes to be identified by clustered, nominally positive SNPs from each of two samples is not as stringent as the criterion that the same SNPs produce nominally positive results in each of two samples. It does allow for within-locus heterogeneity. The degree of convergent identification of genes by data from each of these two samples was never observed by chance in any of 100,000 Monte Carlo simulation trials (p < 0.00001).
