Chunk #138 — IV. Results of tests of clustering within individual samples and tests of convergence between replicate samples for the same phenotypes — C. Bipolar disorder vs control (Samples 7, 8 and 9)
WTCCC bipolar vs control 28,192 of the 426,604 SNPs analyzed in the WTCCC bipolar disorder collection displayed χ2 values with p < 0.05 [1]. 12,560 of these SNPs fell into 1,775 clusters in which at least 4 SNPs that each displayed p < 0.05 (and were sampled on at least two array types) lay within 25 kb of each other. Monte Carlo simulation trials that assessed the probabilities that these results were due to chance found that none of 100,000 simulation trials identified as many clusters of SNPs that displayed nominally-positive differences between bipolar vs controls (control and other disease) samples as were actually identifed (thus p < 0.00001) [1].
