Chunk #139 — IV. Results of tests of clustering within individual samples and tests of convergence between replicate samples for the same phenotypes — C. Bipolar disorder vs control (Samples 7, 8 and 9)
NIMH bipolar vs control 32,835 of the 536,288 SNPs analyzed in the NIMH bipolar collection [2] displayed t values with p < 0.05. 9,971 of these SNPs fell into 1,770 clusters in which at least 4 SNPs that each displayed t values corresponding to p < 0.05 lay within 25 kb of each other. Monte Carlo simulation trials that assessed the probabilities that these results were due to chance found that none of 100,000 simulation trials identified as many clustered SNPs that displayed nominally-positive differences between bipolar vs control samples as were actually identified from this work (thus p < 0.00001).
