Chunk #140 — IV. Results of tests of clustering within individual samples and tests of convergence between replicate samples for the same phenotypes — C. Bipolar disorder vs control (Samples 7, 8 and 9)
German bipolar vs control 27,057 of the 532,835 SNPs analyzed in the German samples displayed t values that corresponded to p < 0.05. 6,110 of these SNPs fell into 1,137 clusters in which at least 4 SNPs that each displayed t values corresponding to p < 0.05 lay within 25 kb of each other [2]. Monte Carlo simulation trials that assessed the probabilities that these results were due to chance found that none of 100,000 simulation trials identified as many clustered SNPs that displayed nominally-positive differences between bipolar vs control samples as observed in this work (thus p < 0.00001).
