Transcriptional response to acute-ethanol within 3 regions of mesocorticolimbic reward circuit across the BXD family.(A) Number of genes found to be significantly ethanol-responsive in the prefrontal cortex (PFC, n = 29), nucleus accumbens (NAc, n = 37) and ventral midbrain (VMB, n = 37) by analysis of saline vs ethanol S-scores across BXD, B6 and D2 samples. (B) Venn-diagram depicting which subsets of ethanol-responsive genes are region specific (blue), overlap across two regions (grey) or common to all three regions (red). All three pairwise overlap combinations were statistically significant as determined by Fisher's Exact Test for count data. Odds ratios from this analysis are depicted in word bubbles.
