Acute ethanol transcriptional response profiles.(A) Strain frequency distributions of gene transcriptional-response classes based on PFC S-score analysis. S-scores >2 indicate a gene was up-regulated by acute ethanol, S-scores <2 indicate down-regulation and S-scores between these thresholds were considered unchanged. (B) S-score strain distributions for three significantly ethanol responsive genes that each represent a different class of ethanol response profile.