As demonstrated in other studies (Schuckit et al., 1997a; Schuckit et al., 2003; Schuckit and Smith, 2004; Schuckit et al., 2005b; Schuckit et al., 2006; Schuckit et al., 2007; Ray et al., 2011), we found a robust relationship between RDH and SRE measures. There was an additional gender-related influence on drinks per drinking day and quantity of alcohol drinks. As demonstrated in other studies (Schuckit et al., 2005a), male participants in this study were more likely to have higher SRE scores which, in turn, may translate into a lower LR. Generally, this is to be expected since males and females differ in quantity of alcohol, maximum drinks consumed, and amount consumed per drinking day. Decreased alcohol dehydrogenase enzymes, reduced alcohol volume distribution, higher hepatic oxidation levels, and diminished gastric emptying in females, compared to males, may contribute to fewer drinks per drinking day and quantity of alcohol consumption (Baraona et al., 2001). This influence of gender did not diminish even after accounting for body weight in the sample.
