Carriers of the rs3778150-C allele exhibited significantly lower levels of overall alcohol sensitivity compared to rs3778150-T homozygous individuals, as measured by higher SRE-Total scores (β = .12, t(244) = 2.11, p = 0.036; ΔR2 = 0.014), lower levels of alcohol sensitivity during the most recent consecutive three month period in which they drank (i.e., higher SRE-3month scores: β = .13, t(237) = 2.18, p < 0.030; ΔR2 = 0.016), and lower levels of alcohol sensitivity during the period of heaviest drinking in their lives (i.e., higher SRE-Heavy scores: β = .13, t(244) = 2.21, p = 0.028; ΔR2 = 0.015). The rs3778150 variant was not significantly associated with levels of alcohol sensitivity during their first five drinking episodes (SRE-First5), nor did the rs1799971 genotype show significant association with any of the SRE measures (Table 2).
