Similar to the results based on the SRE, carriers of the rs3778150-C allele exhibited significantly lower levels of overall alcohol sensitivity compared to rs3778150-T homozygous individuals, as measured by higher ASQ-Total scores (β = .14, t(258) = 2.61, p = 0.010; ΔR2 = 0.019). Carriers of the rs3778150-C allele also exhibited significantly lower levels of alcohol sensitivity to the sedating effects of alcohol compared to rs3778150-T homozygous individuals, as measured by higher ASQ-Heavy scores (β = .21, t(254) = 3.90, p < 0.001; ΔR2 = 0.042). However, the rs3778150 genotype was not significantly associated with sensitivity to the stimulating effects of alcohol (i.e., ASQ-Light), nor did the rs1799971 genotype show significant association with any of the ASQ measures (Table 3).
