Larger studies of common genetic variation, studies of rare variation (including those based on imputation, exome chips and sequencing), and improved computational tools will continue to identify genetic variants associated with BMI and help to further refine the biology of obesity. The 97 loci identified here represent an important step in understanding the physiological mechanisms leading to obesity. These findings strengthen the connection between obesity and other metabolic diseases, enhance our appreciation of the tissues, physiological processes, and molecular pathways that contribute to obesity, and will guide future research aimed at unravelling the complex biology of obesity.
