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Chunk #25 — METHODS — Study design

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Genetic studies of body mass index yield new insights for obesity biology.
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We conducted a two-stage meta-analysis to identify BMI-associated loci in European adults (Extended Data Fig. 1 and Extended Data Table 1). In stage 1 we performed meta-analysis of 80 GWAS (n = 234,069); and stage 2 incorporated data from 34 additional studies (n = 88,137) genotyped using Metabochip7 (Supplementary Tables 1–3). Secondary meta-analyses were also conducted for: (1) all ancestries, (2) European men, (3) European women, and (4) European population-based studies. The total number of subjects and SNPs included in each stage for all analyses is shown in Extended Data Table 1. No statistical methods were used to predetermine sample size.