In terms of genetic risk, the polygenic scores for suicide attempt, depression, and PTSD were associated with a lifetime suicide attempt in persons with an AUD in the meta-analyzed results. Exploration of the stratified results demonstrate these were primarily driven by the associations in the EUR-like participants. The lack of associations of PGSs in the AFR-like grouping likely stems from the relatively small sample sizes of the discovery GWASs (Dudbridge, 2013). Importantly, in the multinomial logistic regression models, those with AUD did not differ in mean levels of AUD PGS regardless of whether they had reported a lifetime suicide attempt. Similar to the logistic regression models limited to persons with AUD, those who had attempted suicide had higher suicide and depression PGSs.
