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Chunk #27 — Discussion

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Clinical, genomic, and neurophysiological correlates of lifetime suicide attempts among individuals with an alcohol use disorder.
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We also observed significant decreases in right hemispheric frontal-parietal theta (3–7 Hz @ F8-F4--P8-P4) and interhemispheric temporal-parietal alpha (7–12 Hz @ T8-P8--T7-P7) EEG resting-state coherences in the resting state among AUD individuals who had attempted suicide. While there are no prior studies of suicide attempt that examined EEG coherence, differences in alpha and theta coherences in frontal, temporal, and parietal regions, and higher beta coherence in frontal and temporal regions were found previously in depressed patients (Leuchter et al., 2012b). Together, these data suggest that while both decreased theta and alpha resting state connectivity are likely among AUD individuals with depression and suicide attempts, but more data are needed to make definitive any conclusions.