Chunk #33 — Results — WGCNA — GWAS enrichment analysis of DE genes and WGCNA modules

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Multi-omics signatures of alcohol use disorder in the dorsal and ventral striatum.

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In the VS, but not in the dorsal striatum, we observed enrichment of DE genes in the GWAS signal of PAU (p = 0.045). In the putamen DE genes were enriched for GWAS signal from a study comparing individuals with OUD to unexposed controls (p = 0.025). None of the DE genes in any of the brain regions showed enrichment for signals from a GWAS of Cannabis Use Disorder or AUD.