In COGA, PRS results aligned with those observed in UK Biobank, with a few exceptions. When both Consumption and Problems PRS were included in the same model, only Consumption PRS showed significant associations with drinks per week, MaxDrinks, and AUD (Table S34). As observed in UK Biobank, when latent factor PRSs and sum score PRSs for the same construct were both included in the multiple regression model, Consumption outperformed AUDIT-C PRS, whereas AUDIT-P PRS outperformed Problems (Table S35). Interestingly, in those models, we found that the strongest associations were between Consumption PRS and AUD, and AUDIT-P PRS and AUD.
