In UK Biobank, we found that both Consumption and Problems PRSs were robustly associated with drinking frequency, drinking quantity, and lifetime AUD (Figure 4). However, Consumption PRS outperformed (i.e., explained more variance) Problems PRS for alcohol consumption phenotypes (Table S32). When the latent factor PRSs and sum score PRSs for the same construct were both included in the multiple regression model (e.g., Consumption and AUDIT-C PRSs), Consumption PRS outperformed AUDIT-C PRS in predicting AUD diagnosis and drinking quantity (but not frequency), while AUDIT-P PRS outperformed Problems PRS across all three phenotypes (Table S33).
