For the allelic analysis, the combined studies of alcohol abuse and dependence produced strong evidence of association with an overall P value of 3×10−56, the ln (OR) being −1.45 (−1.63, −1.27) with an OR of 0.23 (0.2, 0.28) under the random effects model (due to evidence of significant heterogeneity between studies (P(Q) = 3×10−14)). The subgroup of Asian populations also showed strong association with P value of 7×10−56 (Table 1).
