We identify no loci that show genome-wide significance for allele frequency differences between BP and SCZ. However, this analysis remains underpowered from smaller sample size and fewer available well matched BP cases and SCZ cases as it is still uncommon for a single site to collect matching disease samples for this type of analysis. We anticipate that larger studies of this type will discover significant loci. We present a comparison of odds ratios in our independent BP and SCZ samples for a set of 22 previously identified genome-wide significant loci (Figure 3). This result implies that there are additional SCZ loci that will also be independently associated BP loci as sample sizes increase, but that there are also loci that are likely to remain SCZ specific and perhaps also BP specific. CACNA1C(39) has already been independently associated in BP and ITIH3-ITIH4 and MAD1L1 have been near the top of the list in the largest BP GWAS performed to date (18). We note two caveats to interpreting these results: 1) there is significant overlap of both the SCZ samples and the
