ITIH3-ITIH4 and MAD1L1 have been near the top of the list in the largest BP GWAS performed to date (18). We note two caveats to interpreting these results: 1) there is significant overlap of both the SCZ samples and the control samples with those used to identify these loci in Ripke et al. which will create a small inflation of effect for SCZ and 2) there will be a general deflation of effect in our BP sample and to a smaller extent in our SCZ sample due to winner’s curse.
