PRS based on our meta-analysis of AD were significantly predictive of AD outcomes in all three tested external cohorts. PRS derived from the unrelated EU GWAS predicted up to 0.51% of the variance in past month alcohol use disorder in ALSPAC (p = 0.0195; Supplementary Figure S10A) and up to 0.3% of problem drinking as indexed by the CAGE screener in GS (p = 7.9E-6; Supplementary Figure S10B). PRS derived from the unrelated AA GWAS predicted up to 1.7% of the variance in alcohol dependence in the COGA AAfGWAS cohort (p = 1.92E-7; Supplementary Figure 10C).
