PKC mediates several effects of chronic psychostimulant exposure. Chronic treatment with nicotine enhances amphetamine-induced dopamine accumulation in slices of rat prefrontal cortex, and this effect is attenuated by chelerythrine.182 In rat NAc, methamphetamine-induced sensitization of extracellular dopamine accumulation is attenuated by intra-NAc injections of chelerythrine.180 Chronic cocaine treatment results in impairment of type 1 mGluR-mediated induction of long-term depression (LTD) in pyramidal neurons of the rat medial prefrontal cortex, an effect that is attenuated by pretreatment with bisindolylmaleimide I (BIS).183
