We conducted 116 single variant tests of 78 SNPs from a “high priority” list of 11 genes that harbor a variant identified by GWAS meta-analyses of smoking or drinking. After correcting for only 116 tests, only one rare (MAC=6) nonsynonymous variant at 9:136521726 in DBH was significantly associated with the nicotine (exposed) phenotype. The remaining p-values were uniformly distributed and non-significant. The full table and QQ plot of 116 tests are in Table S4 and Figure S10 (see Supplement 1).
