Results from GCTA are displayed in Table 2. In aggregate, rare nonsynonymous SNPs accounted for 19% of the heritability in illicit drugs (p=.01), but did not significantly account for variance in any other phenotype. Marginal effects were observed for aggregate nonsynonymous effects on behavioral disinhibition and alcohol dependence. Common SNPs, on the other hand, accounted for 27% and 26% of the variance in illicit drugs and behavioral disinhibition, which is less than half of the pedigree-based heritability of those traits. When considering all variants, the SNPs significantly account for 46% and 40% of the variance in illicit drugs and behavioral disinhibition. When considering the heritability of these traits is 55% and 58%, respectively, we find that the combination of rare nonsynonymous and genome-wide common variants account for 84% of the heritability in the illicit drug phenotype, and 69% of the behavioral disinhibition phenotype.
