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Chunk #45 — Discussion

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Genomewide association studies: history, rationale, and prospects for psychiatric disorders.
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Bearing these risks and caveats in mind, we conclude that GWAS methods have discovered a remarkable set of robust common SNP association findings for a broad range of diseases, now including an initial set of SNP and CNV associations for psychiatric disorders. It is reasonable to predict that studies of sufficiently large samples can produce definitive discoveries of genetic risk factors for psychiatric disorders, and that these discoveries will contribute to the definitive identification of pathophysiological mechanisms for the first time.