Over the course of this commentary, we hope to accomplish four goals: (1) identify why sex differences are important to consider in the context of genetics; (2) establish evidence that sex differences are not being considered in human genetics; (3) provide compelling counter-arguments to the traditional reasons given for not considering sex differences in genome-wide association studies (GWAS); and (4) offer suggestions on how to test for sex differences in analyses and why it is important to include and report these analyses, no matter the result.