Many fields in biology under-report sex differences and experiments that include this important variable are unfortunately low. Conducting and reporting sex differences in clinical and preclinical research have increased due to government policy, however, it remains an exception to the rule in science as a whole. One discipline, human genetics, has escaped the attention of government regulations and still largely ignores biological sex. There are a number of reasonable explanations for not including sex in human genetics studies (discussed later), but evidence across all levels of biomedical research show that ignoring sex also ignores an important biological context created by our genes, and within which our genes exist.