The Control>Bipolar comparison revealed several regions of significant difference, with the largest cluster in the medial PFC (Brodmann's Areas 10 and 32). In control but not bipolar disorder subjects, the DMN also included parts of the right premotor cortex, bilateral fusiform gyri, left hippocampus, and the pons (Table 1; Figure 2a). Mean Z-scores within the medial PFC cluster were 3.76±0.55 in controls and 2.75±0.48 in bipolar disorder (Figure 2a). By contrast, the left parietal cortex, left fusiform gyrus, right visual and auditory association cortices, left frontal polar cortex and the pons had significantly more coherence with the DMN in the Bipolar > Control comparison (Table 1; Figure 2b). Mean Z-scores in the left parietal cluster were 1.49±0.29 in bipolar disorder and 0.41±0.25 in controls (Figure 2b).
