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Chunk #21 — 3. RESULTS — 3.1. Differences in DMN — 3.1.2. Schizophrenia vs. control subjects

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Default mode network abnormalities in bipolar disorder and schizophrenia.
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In the Control>Schizophrenia comparison, DMN spatial extent was significantly greater in the dorsal anterior cingulate cortex (Brodmann's Area 24) (Table 1; Figure 3a). Mean Z-scores in this cluster were 1.52±0.31 in controls and 0.27±0.19 in schizophrenia subjects (Figure 3a). The complementary Schizophrenia>Control comparison revealed that the left frontal polar cortex, right dorsolateral prefrontal cortex and multiple regions within the basal ganglia have greater coherence with the DMN (Table 1; Figure 3b). Mean Z-scores averaged across the basal ganglia clusters were 1.04±0.12 in schizophrenia subjects and 0.06±0.09 in controls (Figure 3b).