Chunk #25 — Candidate Gene Association Studies for Alcohol and Nicotine Dependence — Other Candidate Genes — Genes Potentially Associated with Multiple Disorders
Linkage analyses demonstrated that the region containing the CHRM2 gene contributed to electrophysiological differences as well as to the risk of alcohol dependence and major depression. (Jones et al, 2004). Subsequent association studies both in the COGA sample and in an independent sample identified several SNPs in the CHRM2 gene that were associated with alcohol dependence, major depression, and comorbid alcoholism and depression, as well as with electrophysiologic measures (Wang et al. 2004; Luo et al. 2005). Thus, the CHRM2 gene appears to contribute to multiple alcohol-related phenotypes.
