The LBC1936 has quantitative measures of symptoms of anxiety, depression and the personality trait of neuroticism, plus psychometrically tested measures of cognitive ability (fluid (age sensitive) and crystallised (non-age sensitive)) and cognitive ageing,60, 64 which have been shown to be highly heritable and polygenic.65, 66 Association of these traits with DISC1 was tested by linear regression analyses, co-varied for age at testing and sex (Supplementary Figures S6–S8). There were no region-wide significant findings for any of these quantitative traits.
