The other 3 top loci in the primary analysis are located within large intergenic regions. rs13063502 on 3q13.1 lies between the non-coding cDNA FLJ25363 and PVRL3, which resides 1.5 Mb telomeric to rs13063502 and is expressed primarily in placenta and testis.41 rs769111 on 7p21.3 is situated between THSD7A, a gene expressed almost exclusively in developing endothelial cells42, and TMEM106B, a gene recently associated with fronto-temporal dementia with TDP-43 inclusions (FTD-TDP), whose primary function in the brain remains to be elucidated.43 Lastly, rs7336083 lies in a 1.9 Mb intergenic region between SLITRK1 and SLITRK6 on chromosome 13q31. While SLITRK1 is an a priori candidate TS susceptibility gene based on previous identification of both rare functional variants12 and common haplotypes44 in TS patients, functional annotation indicates that rs7336083 is a cerebellar eQTL of SLITRK6. Candidate gene analysis of all genotyped SNPs within 50 kb of SLITRK1 identified no nominally associated SNPs (Table S9), including two SNPs recently reported to be associated with TS in a separate European-ancestry sample45 (rs9593835 and rs9546538; p=0.52 and p=0.98 respectively in this study). Of note, the association
