50 kb of SLITRK1 identified no nominally associated SNPs (Table S9), including two SNPs recently reported to be associated with TS in a separate European-ancestry sample45 (rs9593835 and rs9546538; p=0.52 and p=0.98 respectively in this study). Of note, the association signals in rs7336083 and rs13063502 decreased in the secondary meta-analysis (Figures S11-S12, Table S3). It remains to be determined whether these signal reductions are indicative of false positive associations, random signal fluctuations, or genetic heterogeneity between the European ancestry samples and the Latin American CVCR/ANT samples used in the secondary analysis.
