We then repeated the process with the H3K4me3 fetal brain annotation (though with just one annotation instead of 10 cell-type-groups). First we fit a model with this annotation plus the baseline model to the schizophrenia summary statistics [18]. We then scaled the coefficient of the cell-type-specific annotation until the mean z-score over 500 replicates matched the mean z-score in real data. In a second set of simulations, we decreased the coefficient so that that the top cell-type group was significant in 50% of 500 replicates.
