In this study, we identified mRNA and miRNA co-expression modules differentially expressed in a matched AD case-control postmortem sample, including cell type-specific associations and the differential enrichment of biological processes therein. Our results corroborate previously reported findings in the literature; however, we are first to identify the dysregulation of these processes in the NAc of human alcoholics. While central to the MCL system, the NAc also acts in conjunction with other critical brain regions, and we believe our study advances our knowledge of the effect of alcohol on this prominent reward/reinforcement circuit.
