shown to regulate dendritic calcium levels in hippocampal neurons and was differentially expressed in the NAc, PFC, and VTA of an acute ethanol response mouse model [82, 83]. AP1S1, a clathrin-related protein involved in membrane trafficking and endocytosis, as well as the causal gene for MENDIK (mental retardation, enteropathy, deafness, neuropathy, ichthyosis and keratoderma) syndrome, was differentially expressed in the PFC of chronic alcoholics [9, 84]. Although we did not observe significant enrichment of AD GWAS signals among our significant eQTLs for miRNA hubs, NNAT and PSMB5 from neuronal expression-associated mRNA modules, M yellow and M turquoise, respectively, were both cooperatively targeted by hsa-miR-34 family miRNAs. It is possible that hsa-miR-34 family miRNAs exhibit trans-eQTL effects with variants associated with NNAT and PSMB5; however, as this analysis requires much larger samples, we did not have the power test this hypothesis here.
