Chunk #13 — Results — Effects of Age, Sex, and Other Factors on ZNF804A Transcripts Across the Life Span

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Expression of ZNF804A in human brain and alterations in schizophrenia, bipolar disorder, and major depressive disorder: a novel transcript fetally regulated by the psychosis risk variant rs1344706.

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Both ZNF804A transcripts were detected across the entire age range (Figure 1), being preferentially expressed fetally relative to postnatal life (ZNF804A: 1.98-fold higher expression, P < .001; ZNF804AE3E4: 2.63-fold higher expression, P < .001). Overall, ZNF804AE3E4 is more abundant than full-length ZNF804A mRNA (3.79-fold higher expression, P < .001). Their lifetime expression trajectories were similar—both transcripts decreased by similar amounts during infancy and childhood (11% decrease per year on average; full length: P < .001; truncated: P = .01) but remained constant across adulthood.