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Chunk #14 — Results — Effects of Age, Sex, and Other Factors on ZNF804A Transcripts Across the Life Span

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Expression of ZNF804A in human brain and alterations in schizophrenia, bipolar disorder, and major depressive disorder: a novel transcript fetally regulated by the psychosis risk variant rs1344706.
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There was no main effect of sex on either transcript across the life span, but ZNF804A mRNA was more highly expressed in men compared with women (1.20-fold higher expression, P = .02). There were significant effects of both RIN and PMI on the full-length transcript (RIN: P < .001; PMI: P = .03), but only RIN was associated with levels of the truncated transcript (P < .001). There were differences in ZNF804AE3E4 expression levels between the small set of Hispanic participants (n = 7; 1.90-fold lower expression, P = .02) and Asian participants (n = 6; 1.85-fold higher expression, P = .04) compared with white participants; there were no differences between African American and white participants or any racial differences in the expression of the full-length transcript.