We examined whether the 2 transcripts are differentially expressed in patients with schizophrenia, bipolar disorder, and major depressive disorder in DLPFC. As shown in Figure 2, ZNF804AE3E4 mRNA was increased in major depressive disorder (1.45-fold higher expression, P < .001) and decreased in schizophrenia (1.22-fold lower expression, P = .006). In contrast, full-length ZNF804A mRNA was unaltered in schizophrenia and major depressive disorder and reduced in bipolar disorder (1.17-fold lower expression, P = .01). The ZNF804AE3E4 to ZNF804A mRNA ratio was associated with all 3 disorders: it was elevated in bipolar disorder (P = .002) and major depressive disorder (P < .001) and decreased in schizophrenia (P = .001). There were no significant diagnosis-by-sex interactions affecting either transcript.
